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Title: Cohort R81: Hepatitis B
Summary: In 1942, a hepatitis epidemic arose among Army servicemen due to yellow fever vaccine lots contaminated with hepatitis B. Three groups were assembled to enable follow-up. Exposed-Ill are servicemen who were hospitalized during the epidemic with hepatitis. Exposed-Not Ill are servicemen who were injected with contaminated vaccine lots, but did not become obviously ill (potentially subclinical). Comparisons are servicemen who were vaccinated with uncontaminated lots.
References:
Seeff LB, Beebe GW, Hoofnagle JH, et al. A Serologic Follow-up of the 1942 Epidemic of Post-Vaccinal Hepatitis in the United States Army. N Engl J Med 1987(April);316(16):965-970.
Norman JE, Beebe GW, Hoofnagle JH, Seef, LB. Mortality Follow-up of the 1942 Epidemic of Hepatitis B in the U.S. Army. Hepatology 1993;18(4):790-797.
Keywords: hepatitis; mortality; yellow fever vaccine; jaundice
Cohort Characteristics: 83,498 total records
|
Data item |
Exposed-III
(31,440) |
Exposed-Not III
(23,656) |
Comparison
(28,402) |
|
Military service number: |
100% complete |
100% complete |
100% complete |
|
Social security number: |
38% complete |
46% complete |
40% complete |
|
VA claim folder number: |
75% complete |
77% complete |
79% complete |
|
Full name: |
100% complete |
100% complete |
100% complete |
|
Sex: |
100% complete |
100% complete |
100% complete |
|
Male: |
100% |
100% |
100% |
|
Race: |
90% complete |
45% complete |
70% complete |
|
White: |
96% |
96% |
91% |
|
Black: |
3% |
2% |
9% |
|
Other: |
1% |
2% |
|
|
Date of birth: |
99% complete |
100% complete |
100% complete |
|
Mean year of birth: |
1916 |
1917 |
1918 |
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Median year of birth: |
1917 |
1917 |
1920 |
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Year of birth range: |
1880-1925 |
1882-1925 |
1881-1925 |
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Vital status as of 1984 - |
|
|
|
|
Crude mortality: |
31% |
33% |
39% |
|
Date of death: |
100% complete |
100% complete |
100% complete |
|
Immediate cause of death: |
29% complete |
33% complete |
15% complete |
|
Underlying cause of death: |
61% complete |
70% complete |
36% complete |
|
Autopsy available: |
13% complete |
18% complete |
8% complete |
|
Date of enlistment: |
47% complete |
50% complete |
44% complete |
|
Date of discharge: |
47% complete |
50% complete |
44% complete |
|
Vaccine lot number: |
100% complete |
100% complete |
Not applicable |
|
Injected with contaminated lot: |
67% |
100% |
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Last Updated: 8/15/2005, 02:01 PM
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