The Institute of Medicine (IOM) report, Review Of ATSDR’s Great Lakes Report Drafts (Letter Report) presents the details of an IOM committee’s evaluation of the Agency for Toxic Substances and Disease Registry (ATSDR) unofficial report drafts looking at health and pollution data from the Great Lakes region, of ATSDR’s response to review, as well as of the concerns of the Office of the Director of ATSDR and the Office of the Director of the Coordinating Center for Environmental Health and Injury Prevention (CCEHIP). The committee found that the two drafts have problems and limitations that diminish the documents' scientific quality. These shortcomings hamper the usefulness of the drafts in addressing whether health risks might be associated with living near the lakes.