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Sponsored by
The Roundtable on Environmental Health Sciences, Research, and Medicine
National Academy of Sciences Auditorium
2101 Constitution Avenue, N.W., Washington, DC
May 16-17, 2001
Wednesday, May 16, 2001
8:30a.m. Welcome and Opening Remarks
The Honorable Paul G. Rogers (Roundtable Chair)
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8:40 a.m. Remarks from the IOM President
Kenneth Shine, M.D.
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8:55 a.m. Remarks and Charge to Participants
Samuel Wilson, M.D., Deputy Director, NIEHS
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9:10 a.m. Statement of Workshop Objectives
Franklin Mirer, Ph.D. (workshop co-chair)
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Alan Nelson, M.D. (workshop co-chair)
9:20 a.m. Overview of Cancer and the Environment
Mr. Samuel Donaldson (ABC News)
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Session I: Link between Environmental Factors and the Development of Cancer
Moderator: Woodie Kessel
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9:50 a.m. Genes and the Environment in Cancer Etiology
Joseph Fraumeni, Jr., M.D. (NCI)
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10:30 a.m. Diet and Other Environmental Factors as Modifiers of Cancer Risk
John Milner, Ph.D. (Penn State University and NCI)
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11:10 a.m.
11:25 a.m. Genetic Epidemiology as a Tool for Gene-Environment Interactions
Break
Kari Hemminki, M.D., Ph.D. (Karolinska Institute)
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12:05 a.m.
The p53 Pathway: At the Crossroads of Molecular Carcinogenesis and Molecular Epidemiology
Curtis C. Harris, M.D. (NCI)
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12:45 p.m. General Discussion
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1:00 p.m. Lunch
Session II: Genetic - Environmental Interaction in Special Populations
Vulnerable Populations
Moderator: Lovell Jones, Ph.D.
1:30 p.m. Health Disparities: Does Gene-Environment Interactions Play a Role?
Lovell Jones, Ph.D. (MD Anderson Cancer Center)
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1:50 p.m. Cancer Disparities in Appalachia
Gilbert Friedell, M.D. (Markey Cancer Center)
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2:05 p.m. Migrant Farmworkers’ Children and Pesticides: A High-Risk Population
Maria Hernandez-Valero, Dr.PH (MD Anderson Cancer Center)
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2:20 p.m. Priorities and Special Populations: Ties That Bind
Armin Weinberg, Ph.D. (Baylor College of Medicine)
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2:35 p.m. General Discussion
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2:50 p.m. Break
Cancer in Children
3:20 p.m. Childhood Cancer and Diet: Preliminary Evidence
Greta Bunin, Ph.D. (Children’s Hospital of Philadelphia)
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3:35 p.m. Trends: Incidents and Survivorship
Leslie Robison, Ph.D. (University of Minnesota)
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3:50 p.m. Chemicals and Chromosomes, Children and Cancer, Clusters and Cohorts in a New Century
Richard Jackson, M.D. (CDC)
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4:10 p.m. General Discussion
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Women and Cancer
4:25 p.m. Epidemiology and Genetic Susceptibility to Breast Cancer
Brian Henderson, M.D. (University of Southern California, Keck School of Medicine)
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4:40 p.m. Gene-Environment Risk Factors for Breast Cancer
Mary Wolff, Ph.D. (Mount Sinai School of Medicine)
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4:55 p.m. Breast Cancer Genetics: BRCA1 and BRCA2 Genes
Olufunmilayo Olopade, M.D. (Chicago University, Pritzker School of Medicine)
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5:10 p.m. General Discussion
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5:30 p.m. Reception
Thursday, May, 17 2001
8:30 a.m. Welcome Back
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8:35 a.m. Cancer Treatment Based on Immune Stimulation
Steven Rosenberg, M.D., Ph.D. (NCI)
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Session III: Genetic - Environmental Interaction in Specific Cancers
Lung Cancer
Moderator: John Minna, M.D.
9:30 a.m. Molecular Pathogenesis of Lung Cancer
John Minna M.D. (University of Texas Southwestern Medical Center)
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9: 50 a.m. Genetic Susceptibility to Lung Cancer
Margaret Spitz, M.D., M. PH (MD Anderson Cancer Center)
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10:10 a.m. General Discussion
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10:30 a.m. Break
Colon Cancer
10:50 a.m. Environmental and Genetic Factors Involved in Colorectal Carcinogenesis
Raymond DuBois, M.D., Ph.D. (Vanderbilt University)
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11:10 a.m. Environmental Issues related to Colon Cancer
David Alberts, M.D. (Arizona Cancer Center)
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11:30 a.m. General Discussion
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Prostate Cancer
11:50 a.m. Similarities of Prostate and Breast Cancer: Evolution, Diet and Estrogens
Donald Coffey, Ph.D. (Johns Hopkins University)
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12:10 a.m. The Effect of Herbal Therapies in Prostate Cancer
Robert S. DiPaola, M.D. (UMDNJ-RWJ Medical School)
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12:30 p.m. General Discussion
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12:50 p.m. Lunch
Session IV: Moving forward
Moderator: Samuel Wilson, M.D.
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1:30 p.m. Introduction and Remarks
The Honorable Paul G. Rogers, J.D.
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Cancer and the Environment: A View from "The Hill"
The Honorable John E. Porter, J.D.
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Roundtable Summation and General Discussion
2:15 p.m.
Summation of the Workshop
Lovell Jones, Ph.D., Roundtable Member
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2:30 p.m.
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Discussion of the workshop and future needs of cancer research.
David Ringer, Ph. D., M.P.H., Scientific Program Director, American Cancer Society
Lovell Jones, Ph.D., Professor, Gynecologic Oncology, MD Anderson Cancer Center
Ms. Susan Braun, President and CEO, Susan G. Komen Breast Cancer Foundation
Ms. Linda Frame, Senior Clinical Advisor, Susan G. Komen Breast Cancer Foundation
Martha Linet, M.D. M.P.H., National Cancer Institute
Donald Coffey, Ph.D., Johns Hopkins University
4:00 p.m. Adjournment
Roundtable discussion
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