To devise strategies for reducing human exposure to DLCs from the food supply, the National Science and Technology Council’s Interagency Working Group on Dioxin with support from the U.S. Department of Agriculture, the U.S. Department of Health and Human Services, and other agencies and sponsors, requested the help of the Institute of Medicine of the National Academies. The resulting study, Dioxins and Dioxin-like Compounds in the Food Supply: Strategies to Decrease Exposure, recommends policy options to reduce exposure to these contaminants while considering how implementing these options could both reduce health risks and affect nutrition, particularly in sensitive and highly exposed groups, if dietary changes are suggested.