Institute of Medicine
Committee on Methodological Challenges in HIV Prevention Trials
Public Meeting
Radisson Edwardian Kenilworth Hotel
Bloomsbury Suite
97 Great Russell Street
London WC1B 3LB

April 19, 2007

AGENDA

8:30 – 8:40 a.m.
Welcome and Overview
Steve Lagakos, Ph.D. (Chair), Professor of Biostatistics, Department of Biostatistics, Harvard School of Public Health

Issues in Trial Design and Implementation

8:40 – 9:05 a.m.
(20 minutes; 5 Q&A)
Site preparedness and implementation of late-stage HIV prevention efficacy trials in resource-limited settings
Gita Ramjee, Ph.D., Director, South African Medical Research Council, HIV Prevention Unit

9:05 – 9:30 a.m.
(20 minutes; 5 Q&A)
Context, challenges, and new ideas for HIV prevention trials
Helen Rees, O.B.E. , Executive Director, Reproductive Health and HIV Research Unit, Department of Obstetrics and Gynecology, University of the Witwatersrand

9:30 – 9:55 a.m.
(20 minutes; 5 Q&A)
Accuracy of self-reported sexual behavior
James J. Jaccard, Ph.D., Professor, Department of Psychology, Florida International University

9:55 – 10:10 a.m.
BREAK

10:10 – 10:35 a.m.
(20 minutes; 5 Q&A)
Measurement of adherence, sexual behavior, and product acceptability in MDP PRO 2000 microbicide trial
Robert Pool, Ph.D., Senior Lecturer in Social Anthropology, London School of Hygiene & Tropical Medicine

10:35 –11:00 a.m.
(20 minutes; 5 Q&A)
Issues in microbicide trial design, monitoring, and analysis
Andrew Nunn, MSc., Associate Director, Medical Research Council (MRC), Clinical Trials Unit

11:00 –11:25 a.m.
(20 minutes; 5 Q&A)
Microbicide Product Development and Implications for Future Trials
Robin Shattock, Ph.D., Reader in Cell Biology of Infection, Department of Cellular and Molecular Medicine, St. George’s Hospital Medical School

11:25 – 12:15 p.m
Panel Discussion

12:15 – 1:00 p.m.
LUNCH  

HIV Prevention Trials (Non-PrEP or Microbicide)

1:00 – 1:25 p.m.
(20 minutes; 5 Q&A)
Male Circumcision to Prevent HIV Acquisition in Young Men in Kisumu, Kenya
Kawango Agot, Ph.D., M.P.H. Coordinator and Co-Investigator, Universities of Nairobi, Illinois and Manitoba (UNIM) Project; Lumumba Health Center, University of Nairobi, Kenya

1:25 – 1:50 p.m.
(20 minutes; 5 Q&A)
Male Circumcision to Prevent HIV Acquisition and Transmission in Rakai, Uganda
Maria J. Wawer, M.D.,M.P.H. Professor, Department of Population, Family, and Reproductive Health, Bloomberg School of Public Health Johns Hopkins University

1:50 – 2:15 p.m.
(20 minutes; 5 Q&A)
Lessons learned from STD treatment trials for HIV prevention
Maria J. Wawer, M.D., M.P.H Professor, Department of Population, Family, and Reproductive Health
Bloomberg School of Public Health Johns Hopkins University

2:15 – 2:40 p.m.
(20 minutes; 5 Q&A)
Phase III Randomized Placebo-Controlled Trial of HSV-2 Suppression to Prevent HIV Transmission among HIV-Discordant Couples
Connie Celum, M.D., M.P.H, Professor of Medicine & Adjunct Professor of Epidemiology
Division of Allergy and Infectious Diseases, University of Washington
School of Medicine

2:40 – 3:00 p.m.
Break

3:00 – 4:00 p.m.
Panel Discussion

4:00 – 4:30 p.m.
(20 minutes; 10 Q&A)
The latex diaphragm to prevent HIV acquisition among women: A female-controlled, physical barrier of the cervix
Nancy Padian, Ph.D., M.P.H., Executive Director of Research, Global Health Sciences, Professor, Departments of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco

4:30 – 5:00 p.m.
(20 minutes; 10 Q&A)
Key Summary Points and Discussion
Kenneth H. Mayer, M.D., Professor of Medicine and Community Health, Director, Brown University AIDS Program, Brown University, Attending physician, Division of Infectious Diseases, The Miriam Hospital, Research Medical Director, Fenway Community Health

5:00 p.m.   
Adjourn

5:15 – 6:30 p.m.            
Reception