July 15-16, 2003
8:00 a.m. to 5:00 p.m.

National Academy of Sciences Auditorium
2100 C Street, NW
Washington, DC

Sponsored by the
Bill and Melinda Gates Foundation

TUESDAY, JULY 15  

8:00 AM
WELCOME REMARKS  
Jerome Strauss, M.D., Ph.D., University of Pennsylvania

INTRODUCTION TO SYMPOSIUM
Allan Rosenfield, M.D., Columbia University
See slides

8:30 AM
DISCOVERY APPROACH TO TARGET SELECTION AND VALIDATION
Moderator: Robert Braun, Ph.D., University of Washington
Moderator: Martin Matzuk, M.D., Ph.D., Baylor College of Medicine

Insights from the testicular transcriptome: Michael Griswold, Ph.D., Washington State University
See slides

Proteomics and the discovery of contraceptive drug and vaccine targets: John C. Herr, Ph.D., University of Virginia

• See slides part 1
• See slides part 2
• See slides part 3
• See slides part 4

Toward a comprehensive analysis of the genetic control of male fertility: Barbara Wakimoto, Ph.D., University of Washington

• See slides part 1
• See slides part 2

10:00 AM
BREAK

10:15 AM
Towards the genetics of mammalian reproduction: Induction and mapping of gametogenesis mutants in mice: John Schimenti, Ph.D., The Jackson Laboratory

Model organisms: The use of xenopus laevis as a potential model for contraceptive research: Laurence D. Etkin, Ph.D., MD Anderson Cancer Center
See slides

Trapping participants of the oocyte-granulosa cell regulatory loop as potential contraceptive targets: John Eppig, Ph.D., The Jackson Laboratory
See slides

11:15 AM
FROM TARGET SELECTION TO PRODUCT DEVELOPMENT
Moderator: Gregory S. Kopf, Ph.D., Wyeth Research
Charles Grudzinskas, Ph.D., Drug Development Consultant
See slides

12:15 PM
LUNCH

1:15 PM
FUNCTIONAL TARGETS FOR CONTRACEPTION
Moderator: Linda Giudice, Ph.D., Stanford University
Moderator: Gregory S. Kopf, Ph.D., Wyeth Research  

Leptin peptide antagonists: Down-regulation of leptin actions in embryo implantation: Ruben Gonzalez, Ph.D., Boston Biomedical Research Institute

• See slides part 1
• See slides part 2

Gamete membran fusion: A genetic approach: Diana Myles, Ph.D., University of California, Davis

Using chemical genetics to study regulators of fertility: Caroline Shamu, Ph.D., Harvard Medical School
See slides

2:45 PM
BREAK

3:00 PM
SMALL GROUP DISCUSSIONS

STD Prevention and Contraception: Should research be pursued jointly or separately?
Moderator: Nancy Padian, Ph.D., University of California, San Francisco

Target Selection: What criteria should be used to select promising targets?
Moderator: Jerome Strauss, M.D., Ph.D., University of Pennsylvania

Adoption of Contraceptives: What are the challenges associated with adopting contraceptives and how can they be overcome?
Moderator: Jacqueline Darroch, Ph.D., Alan Guttmacher Institute

Immunological Approaches and Contraceptive Research: What is the future outlook?
Moderator: Michael Harper, Ph.D., Sc.D., CONRAD

Evaluation of Contraceptives: What are the obstacles to preclinical evaluation and proof of concept in contraceptive development and how can they be overcome?
Moderators: Marlene Cohen, Ph.D., Independent Consultant;  Ruth Merkatz, Ph.D., R.N., Pfizer

5:00 PM
ADJOURN

WEDNESDAY, JULY 16

8:00 AM
ADVANCES IN MATERIALS SCIENCE
Moderator: Lisa Brannon-Peppas, Ph.D., University of Texas, Austin

Overview of controlled release: Thomas Tice, Ph.D., Southern Research Institute
See slides

An overview of controlled release technology in contraceptive devices: Camilla Santos, Ph.D., Spherics, Inc
See slides

Development of injectible, biodegradable microsphere products for sustained drug delivery: Mark Tracy, Ph.D., Alkermes, Inc.

9:30 AM
BREAK

9:45 AM
CASE STUDIES IN CONTRACEPTIVE DEVELOPMENT
Moderator: Anna Glasier, M.D., University of Edinburgh

Contraceptive microbicide development: Lessons from mucosal ecology: Kevin Whaley, Ph.D., Epicyte Pharmaceutical, Inc.; Johns Hopkins University; ReProtect, Inc.; Mapp Pharmaceutical, Inc.
See slides

Male hormonal contraception: William Bremner, M.D., Ph.D., University of Washington
See slides

Biosyn/C31G: Anne Marie Corner, M.B.A., Biosyn; Daniel Malamud, Ph.D., University of Pennsylvania; Kurt Barnhart, M.D., University of Pennsylvania

• See Corner slides
• See Malamud slides
• See Barnhart slides

11:45 AM
LUNCH

12:45 PM
CHALLENGES AND SOLUTIONS IN CONTRACEPTIVE PRODUCT DEVELOPMENT AND EVALUATION
Moderator: Regine Sitruk-Ware, M.D., Population Council

Challenges and solutions in contraceptive product development and evaluation: A U.S. regulatory perspective: Lisa Rarick, M.D.
See slides 

Giving choices in family planning: Paul F.A. Van Look, M.D., Ph.D., World Health Organization
See slides

Applicability of contraceptive research to the needs of women in developing countries: Ellen Elizabeth Hardy, Ph.D., Universidade Estadul de Campinas, Brazil
See slides

Exploring user issues that affect contraceptive development and introduction: Kim Dickson-Tetteh, M.D., Reproductive Health Research Unit, South Africa
See slides

2:45 PM
BREAK

3:00 PM
PANEL DISCUSSION
Moderator:  Nancy Padian, Ph.D., University of California, San Francisco

Diana Blithe, Ph.D., National Institute of Child Health and Human Development, National Institutes of Health
Laneta Dorflinger, Ph.D., Family Health International
Henry Gabelnick, Ph.D., CONRAD
Maurizio Macaluso, M.D., Dr.P.H., Centers for Disease Control and Prevention
Jeffrey Spieler, U.S. Agency for International Development