Summary excerpt from the Statement of The Children's Cause: The Children’s Cause appreciates the opportunity to submit written comments to the Institute of Medicine (IOM) Committee on Clinical Research Involving Children. The Children’s Cause is a consumer-based, independent advocacy voice of families and survivors on national policies that affect research, healthcare, and services for children with cancer. Our mission is to foster the rapid and safe development of new treatments, quality health and follow-up care for patients and long-term survivors of childhood cancer.