Institute of Medicine, Food and Nutrition Board
Development of DRIs, 1994-2004: Lessons Learned and New Challenges
Washington, DC
September 18-20, 2007
DAY 1-September 18
INTRODUCTION
8:30-9:00 Welcome and Opening Remarks
John Suttie, Chair, University of Wisconsin
9:00-9:30 Overview of Current DRI Framework and Issues Raised
Christine Taylor, Institute of Medicine
SESSION 1
CONCEPTUAL FRAMEWORK FOR DRI DEVELOPMENT
Moderator: Stephanie Atkinson, McMaster University
10:00-10:40 Current Framework for DRI Development: What Are the Pros and Cons?
Robert Russell, Tufts University
10:40-10:55 Case Study: Applying the DRI Framework to Chronic Disease Endpoints
Paula Trumbo, Center for Food Safety and Applied Nutrition, FDA
10:55-11:10 Case Study: Applying the DRI Framework to Non-chronic Disease Endpoints
Allison Yates, Agricultural Research Service, USDA
11:10-11:50 Discussion - Framework Pros/Cons; Case Studies
Co-discussants: Patsy Brannon, Cornell University
Alice Lichtenstein, Tufts University
11:50-12:20 Two Perspectives: The DRI Framework
Perspective: Janet King, University of California, Berkeley and Davis
1:30-1:45 Evaluating Evidence for DRI Development: What Are the Issues In Applying Systematic Evidence-Based Review Approaches to DRI Development?
Alice Lichtenstein, Tufts University
1:45-2:15 Risk Assessment: Is It a Relevant Organizing Structure?
Elizabeth Yetley, Office of Dietary Supplements, NIH
2:15-2:55 Discussion - Systematic Evidence Based Review; Risk Assessment
Discussant: Sanford Miller, University of Maryland
2:35-2:55 Discussion open to all attendees
3:15-5:15 Panel Discussion 1 - In What Ways Could the Conceptual Framework Be Enhanced?
Panel Members: Cutberto Garza, Boston College
Mary L'Abbe, Health Canada
Irwin Rosenberg, Tufts University
Barbara Stoecker, Oklahoma State University
4:00-5:15 Discussion open to all attendees
DAY 2-September 19
SESSION 2
CRITERIA FOR SCIENTIFIC DECISION-MAKING
Moderator: Robert Russell, Tufts University
8:30-8:50 am Selecting Endpoints: What Are the Issues and What Are the Options for Criteria?
Irwin Rosenberg, Tufts University
8:50-9:00 Discussion
9:00-9:15 Dose-Response Data: Are There Options for Dealing with Limited Data?
Susan Mayne, Yale School of Public Health
9:15-9:30 Discussion
9:30-9:45 Challenges in Addressing Extrapolation/Interpolation for
Unstudied Groups
Stephanie Atkinson, McMaster University
9:45-10:00 Discussion
10:30-10:45 What Are the Challenges in Addressing Adjustment for Data Uncertainty?
Hildegard Przyrembel, Federal Institute for Risk Assessment, Berlin, Germany
10:45-11:00 Discussion
11:00-11:20 Estimating Dietary Intake: What are the Implications for DRI Development?
Amy Subar, National Cancer Institute, NIH
11:20-11:30 Discussion
11:30-11:45 Highlights of Other Important Issues: Physiological, Genomic and Environmental Factors
Cutberto Garza, Boston College
11:45-12:00 Discussion
SESSION 3
GENERAL GUIDANCE FOR USERS OF DRIs
Moderator: Mary Bush, Health Canada
1:00-1:20 pm Overview: Issues Raised About General Guidance for Users
Christine Taylor, Food and Nutrition Board, Institute of Medicine
1:20-1:40 Discussion--- Discussant: Johanna Dwyer, Office of Dietary Supplements, NIH
1:30-1:40 Discussion open to all attendees
1:40-2:05 Special Challenges: Planning and Assessing the Total Diet- What are the Issues and
What are the Options for Enhanced Guidance?
Suzanne Murphy, University of Hawaii
Susan Barr, University of British Columbia
2:05-2:30 Discussion--- Co-discussants: Patricia Guenther, Ctr for Nutr Policy & Promotion USDA
Krista Esslinger, Health Canada
2:20-2:30 Discussion open to all attendees
2:45-3:10 Special Challenges: What are the Issues Related to a Framework for Individual-level and
Group-level Applications?
Valerie Tarasuk, University of Toronto
3:10-3:30 Discussion--- Discussant: Gerard Dallal, Tufts University
:3:20-3:30 Discussion open to all attendees
3:30-5:15 Panel Discussion 2 - In What Ways Could the Guidance for Users of DRIs Be Enhanced?
Panel Members Danielle Brulé, Health Canada
Mary Frances Picciano Office of Dietary Supplements, NIH
William Rand, Tufts University School of Medicine
Linda Van Horn, Northwestern University
DAY 3-September 20
SESSION 4
LOOKING TO THE FUTURE PROCESS FOR DRI DEVELOPMENT
Moderator: Paul Coates, Office of Dietary Supplements, NIH
8:30-8:45 am Emerging Issues: What New Challenges Might the Future Hold?
Catherine Woteki, Mars Inc.
8:45-8:55 Discussion
8:55-9:10 Is There a Need to Enhance Transparency of Decision-Making Process?
Robert Russell, Tufts University
9:10-9:20 Discussion
9:20-9:35 IOM Overview of Options for Stakeholder Input
Linda D. Meyers, Food and Nutrition Board, Institute of Medicine
9:35-9:45 Discussion
9:45-10:00 What are the Options for Criteria for Determining When to Update/Review Existing DRIs?
John Suttie, Chair, University of Wisconsin
10:10-10:25 What Are the Considerations in Specifying "New" Nutrient Substances for DRI Study?
Peter Greenwald, National Cancer Institute, NIH
10:25-10:35 Discussion
10:50-12:45 Panel Discussion 3 - Reflections on What We Have Heard About the Process of DRI Development
Panel Members: Mary Bush, Health Canada
Jean-Pierre Habicht, Cornell University
Suzie Harris, ILSI Research Foundation
Van Hubbard, Div of Nutrition Research Coordination, NIH
Molly Kretsch, Agricultural Research Service, USDA
11:50-12:45 Discussion open to all attendees
12:45-1:15 Summary and Closing Remarks
Chair's Summary (John Suttie)
Closing Remarks from Sponsor Representative (Paul Coates)
Chair's Close of Workshop